School of Biological Sciences, University of Auckland, New Zealand



Young, T., Kesarcodi-Watson, A., Alfaro, A.C., Merien, F., Nguyen, T.V., Mae, H., Le, D.V., Villas-Bôas, S. Differential expression of novel metabolic and immunological biomarkers in oysters challenged with a virulent strain of OsHV-1 (2017) Developmental and Comparative Immunology, 73, pp. 229-245.

Zarate, E., Boyle, V., Rupprecht, U., Green, S., Villas-Boas, S.G., Baker, P., Pinu, F.R. Fully automated trimethylsilyl (TMS) derivatisation protocol for metabolite profiling by GC-MS (2017) Metabolites, 7 (1), art. no. 1, .

Fokin, M., Fleetwood, D., Weir, B.S., Villas-Boas, S. Genome sequence of the saprophytic ascomycete Epicoccum nigrum strain ICMP 19927, isolated from New Zealand (2017) Genome Announcements, 5 (24), art. no. e00557-17, .


Pinu, F.R., De Carvalho-Silva, S., Uetanabaro, A.P.T., Villas-Boas, S.G. Vinegar metabolomics: An explorative study of commercial balsamic vinegars using gas chromatography-mass spectrometry (2016) Metabolites, 6 (3), art. no. 22, . Cited 1 time.

Cecatti, J.G., Souza, R.T., Sulek, K., Costa, M.L., Kenny, L.C., McCowan, L.M., Pacagnella, R.C., Villas-Boas, S.G., Mayrink, J., Passini, R., Franchini, K.G., Baker, P.N., Parpinelli, M.A., Calderon, I.M., Cassettari, B.F., Vetorazzi, J., Pfitscher, L., Filho, E.P.R., Leite, D.F., Feitosa, F.E., Costa e Silva, C.L., Poston, L., Myers, J.E., Simpson, N.A.B., Walker, J.J., Dekker, G.A., Roberts, C.T. Use of metabolomics for the identification and validation of clinical biomarkers for preterm birth: Preterm SAMBA (2016) BMC Pregnancy and Childbirth, 16 (1), art. no. 212, .

Young, T., Alfaro, A.C., Villas-Bôas, S.G. Metabolic profiling of mussel larvae: effect of handling and culture conditions (2016) Aquaculture International, 24 (3), pp. 843-856. Cited 3 times.

Perez-Garcia, O., Chandran, K., Villas-Boas, S.G., Singhal, N. Assessment of nitric oxide (NO) redox reactions contribution to nitrous oxide (N<inf>2</inf>O) formation during nitrification using a multispecies metabolic network model (2016) Biotechnology and Bioengineering, 113 (5), pp. 1124-1136. Cited 2 times.

Mumme, K., Gray, C., Reynolds, C.M., Vickers, M.H., Harrison, C.J., Stanley, J.L., Ruggiero, K., Villas-Bôas, S.G., Baker, P.N., Sulek, K. Maternal-fetal hepatic and placental metabolome profiles are associated with reduced fetal growth in a rat model of maternal obesity (2016) Metabolomics, 12 (5), art. no. 83, .

Tumanov, S., Zubenko, Y., Obolonkin, V., Greenwood, D.R., Shmanai, V., Villas-Bôas, S.G Calibration curve-free GC–MS method for quantitation of amino and non-amino organic acids in biological samples(2016) Metabolomics, 12 (4), art. no. 64, . Cited 1 time.

Hillyer, K.E., Tumanov, S., Villas-Bôas, S., Davy, S.K. Metabolite profiling of symbiont and host during thermal stress and bleaching in a model cnidarian-dinoflagellate symbiosis (2016) Journal of Experimental Biology, 219 (4), pp. 516-527. Cited 3 times.

He, X., de Seymour, J.V., Sulek, K., Qi, H., Zhang, H., Han, T.-L., Villas-Bôas, S.G., Baker, P.N. Maternal hair metabolome analysis identifies a potential marker of lipid peroxidation in gestational diabetes mellitus (2016) Acta Diabetologica, 53 (1), pp. 119-122. Cited 4 times.

Jäpelt, K.B., Christensen, J.H., Villas-Bôas, S.G. Erratum to: Metabolic fingerprinting of Lactobacillus paracasei: The optimal quenching strategy Microb Cell Fact (2015) 14:132 doi 10.1186/s12934-015-0322-5 (2016) Microbial Cell Factories, 15 (1), art. no. 18, .

Anasontzis, G.E., Kourtoglou, E., Villas-Boâs, S.G., Hatzinikolaou, D.G., Christakopoulos, P Metabolic engineering of Fusarium oxysporum to improve its ethanol-producing capability (2016) Frontiers in Microbiology, 7 (MAY), art. no. 632, .


Thomas, M.M., Sulek, K., McKenzie, E.J., Jones, B., Han, T.-L., Villas-Boas, S.G., Kenny, L.C., McCowan, L.M.E., Baker, P.N. Metabolite profile of cervicovaginal fluids from early pregnancy is not predictive of spontaneous preterm birth (2015) International Journal of Molecular Sciences, 16 (11), pp. 27741-27748.

Jäpelt, K.B., Christensen, J.H., Villas-Bôas, S.G. Metabolic fingerprinting of Lactobacillus paracasei: The optimal quenching strategy (2015) Microbial Cell Factories, 14 (1), art. no. 132, . Cited 1 time.

Tumanov, S., Zubenko, Y., Greven, M., Greenwood, D.R., Shmanai, V., Villas-Boas, S.G. Comprehensive lipidome profiling of Sauvignon blanc grape juice (2015) Food Chemistry, 180, pp. 249-256. Cited 4 times.

Dordevic, A.L., Pendergast, F.J., Morgan, H., Villas-Boas, S., Caldow, M.K., Larsen, A.E., Sinclair, A.J., Cameron-Smith, D. Postprandial responses to lipid and carbohydrate ingestion in repeated subcutaneous adipose tissue biopsies in healthy adults (2015) Nutrients, 7 (7), pp. 5347-5361. Cited 2 times.

Granucci, N., Pinu, F.R., Han, T.-L., Villas-Boas, S.G. Can we predict the intracellular metabolic state of a cell based on extracellular metabolite data? (2015) Molecular BioSystems, 11 (12), pp. 3297-3304. Cited 2 times.

Young, T., Alfaro, A.C., Villas-Bôas, S. Identification of candidate biomarkers for quality assessment of hatchery-reared mussel larvae via GC/MS-based metabolomics (2015) New Zealand Journal of Marine and Freshwater Research, 49 (1), pp. 87-95. Cited 4 times.

Lee, T.W., Tumanov, S., Villas-Bôas, S.G., Montgomery, J.M., Birch, N.P. Chemicals eluting from disposable plastic syringes and syringe filters alter neurite growth, axogenesis and the microtubule cytoskeleton in cultured hippocampal neurons (2015) Journal of Neurochemistry, 133 (1), pp. 53-65. Cited 7 times.

Albert, B.B., Derraik, J.G.B., Cameron-Smith, D., Hofman, P.L., Tumanov, S., Villas-Boas, S.G., Garg, M.L., Cutfield, W.S. Fish oil supplements in New Zealand are highly oxidised and do not meet label content of n-3 PUFA (2015) Scientific Reports, 5, art. no. 7928, . Cited 43 times.


Perez-Garcia, O., Villas-Boas, S.G., Swift, S., Chandran, K., Singhal, N. Clarifying the regulation of NO/N2O production in Nitrosomonas europaea during anoxic-oxic transition via flux balance analysis of a metabolic network model (2014) Water Research, 60, pp. 267-277. Cited 18 times.

Greening, C., Villas-Bôas, S.G., Robson, J.R., Berney, M., Cook, G.M. The growth and survival of Mycobacterium smegmatis is enhanced by co-metabolism of atmospheric H (2014) PLoS ONE, 9 (7), art. no. e103034, . Cited 6 times.

Roager, H.M., Sulek, K., Skov, K., Frandsen, H.L., Smedsgaard, J., Wilcks, A., Skov, T.H., Villas-Boas, S.G., Licht, T.R. Lactobacillus acidophilus NCFM affects vitamin E acetate metabolism and intestinal bile acid signature in monocolonized mice (2014) Gut microbes, 5 (3), pp. 296-303. Cited 2 times.

Anasontzis, G.E., Kourtoglou, E., Mamma, D., Villas-Boâs, S.G., Hatzinikolaou, D.G., Christakopoulos, P. Constitutive homologous expression of phosphoglucomutase and transaldolase increases the metabolic flux of Fusarium oxysporum (2014) Microbial Cell Factories, 13 (1), art. no. 43, . Cited 5 times.

Pinu, F.R., Edwards, P.J.B., Gardner, R.C., Villas-Boas, S.G. Nitrogen and carbon assimilation by Saccharomyces cerevisiae during Sauvignon blanc juice fermentation (2014) FEMS Yeast Research, 14 (8), pp. 1206-1222. Cited 3 times.

Perez-Garcia, O., Villas-Boas, S., Singhal, N. A method to calibrate metabolic network models with experimental datasets (2014) Advances in Intelligent Systems and Computing, 294 (AISC), pp. 183-190. Cited 2 times.

Portela, C.A.F., Smart, K.F., Tumanov, S., Cook, G.M., Villas-Bôas, S.G. Global metabolic response of Enterococcus faecalis to oxygen (2014) Journal of Bacteriology, 196 (11), pp. 2012-2022. Cited 4 times.

Pinu, F.R., Edwards, P.J.B., Jouanneau, S., Kilmartin, P.A., Gardner, R.C., Villas-Boas, S.G. Sauvignon blanc metabolomics: Grape juice metabolites affecting the development of varietal thiols and other aroma compounds in wines (2014) Metabolomics, 10 (4), pp. 556-573. Cited 19 times.

de Seymour, J.V., Conlon, C.A., Sulek, K., Villas Bôas, S.G., McCowan, L.M.E., Kenny, L.C., Baker, P.N. Early pregnancy metabolite profiling discovers a potential biomarker for the subsequent development of gestational diabetes mellitus (2014) Acta Diabetologica, 51 (5), pp. 887-890. Cited 16 times.

Sulek, K., Han, T.-L., Villas-Boas, S.G., Wishart, D.S., Soh, S.-E., Kwek, K., Gluckman, P.D., Chong, Y.-S., Kenny, L.C., Baker, P.N. Hair metabolomics: identification of fetal compromise provides proof of concept for biomarker discovery (2014) Theranostics, 4 (9), pp. 953-959. Cited 10 times.


Carreira, R., Rocha, M., Villas-Bôas, S.G., Rocha, I. Algorithms to infer metabolic flux ratios from fluxomics data (2013) Proceedings – 2013 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2013, art. no. 6732490, pp. 205-209.

Erogbogbo, F., May, J., Swihart, M., Prasad, P.N., Smart, K., Jack, S.E., Korcyk, D., Webster, M., Stewart, R., Zeng, I., Jullig, M., Bakeev, K., Jamieson, M., Kasabov, N., Gopalan, B., Liang, L., Hu, R., Schliebs, S., Villas-Boas, S., Gladding, P. Bioengineering silicon quantum dot theranostics using a network analysis of metabolomic and proteomic data in cardiac ischemia. (2013) Theranostics, 3 (9), pp. 719-728. Cited 2 times.

Han, T.-L., Tumanov, S., Cannon, R.D., Villas-Boas, S.G. Metabolic Response of Candida albicans to Phenylethyl Alcohol under Hyphae-Inducing Conditions (2013) PLoS ONE, 8 (8), art. no. e71364, . Cited 6 times.

Bruheim, P., Kvitvang, H.F.N., Villas-Boas, S.G. Stable isotope coded derivatizing reagents as internal standards in metabolite profiling (2013) Journal of Chromatography A, 1296, pp. 196-203. Cited 47 times.

Villas-Boas, S.G. Analytical techniques and applications of metabolomics in systems medicine and systems biotechnology (2013) Computational and Structural Biotechnology Journal, 4 (5), art. no. e201301001, . Cited 1 time.

Portela, C., Villas-Bôas, S., Rocha, I., Ferreira, E.C. Genome scale metabolic network reconstruction of the pathogen Enterococcus faecalis (2013) IFAC Proceedings Volumes (IFAC-PapersOnline), 12 (PART 1), pp. 131-136.


Han, T.-L., Cannon, R.D., Villas-Bôas, S.G. The metabolic response of Candida albicans to farnesol under hyphae-inducing conditions (2012) FEMS Yeast Research, 12 (8), pp. 879-889. Cited 8 times.

Han, T., Cannon, R.D., Villas-Bôas, S.G. Metabolome analysis during the morphological transition of Candida albicans (2012) Metabolomics, 8 (6), pp. 1204-1217. Cited 6 times.

Pinu, F.R., Jouanneau, S., Nicolau, L., Gardner, R.C., Villas-Boas, S.G. Concentrations of the volatile thiol 3-mercaptohexanol in Sauvignon blanc wines: No correlation with juice precursors (2012) American Journal of Enology and Viticulture, 63 (3), pp. 407-412. Cited 11 times.

Aggio, R.B.M., Obolonkin, V., Villas-Bôas, S.G. Sonic vibration affects the metabolism of yeast cells growing in liquid culture: A metabolomic study (2012) Metabolomics, 8 (4), pp. 670-678. Cited 8 times.

Harrison, S.J., Fraser, K., Lane, G.A., Villas-Boas, S.G., Rasmussen, S. Automated high through-put analysis of fractions generated during the isolation of natural products (2012) New Zealand Journal of Agricultural Research, 55 (1), pp. 15-20.

Aggio, R.B.M., Villas-Bôas, S. Raphael bastos mareschi aggio: Bioanalysis young investigator (2012) Bioanalysis, 4 (11), pp. 1285-1286.

Duportet, X., Aggio, R.B.M., Carneiro, S., Villas-Bôas, S.G. The biological interpretation of metabolomic data can be misled by the extraction method used (2012) Metabolomics, 8 (3), pp. 410-421. Cited 37 times.

Wilson, C.M., Aggio, R.B.M., O’Toole, P.W., Villas-Boas, S., Tannock, G.W. Transcriptional and metabolomic consequences of luxS inactivation reveal a metabolic rather than quorum-sensing role for LuxS in Lactobacillus reuteri 100-23 (2012) Journal of Bacteriology, 194 (7), pp. 1743-1746. Cited 17 times.

Frampton, R., Aggio, R.B.M., Villas-Bôas, S.G., Arcus, V.L., Cook, G.M. Toxin-antitoxin systems of Mycobacterium smegmatis are essential for cell survival (2012) Journal of Biological Chemistry, 287 (8), pp. 5340-5356. Cited 31 times.

Harrison, S., Xue, H., Lane, G., Villas-Boas, S., Rasmussen, S. Linear ion trap MS n of enzymatically synthesized 13C-labeled fructans revealing differentiating fragmentation patterns of β (1-2) and β(1-6) fructans and providing a tool for oligosaccharide identification in complex mixtures (2012) Analytical Chemistry, 84 (3), pp. 1540-1548. Cited 16 times.


Sue, T., Obolonkin, V., Griffiths, H., Villas-Bôas, S.G. An exometabolomics approach to monitoring microbial contamination in microalgal fermentation processes by using metabolic footprint analysis (2011) Applied and Environmental Microbiology, 77 (21), pp. 7605-7610. Cited 6 times.

Dhami, M.K., Gardner-Gee, R., van Houtte, J., Villas-Bôas, S.G., Beggs, J.R. Species-Specific Chemical Signatures in Scale Insect Honeydew (2011) Journal of Chemical Ecology, 37 (11), pp. 1231-1241. Cited 11 times.

Harrison, S., Fraser, K., Lane, G., Hughes, D., Villas-Boas, S., Rasmussen, S. Analysis of high-molecular-weight fructan polymers in crude plant extracts by high-resolution LC-MS (2011) Analytical and Bioanalytical Chemistry, 401 (9), pp. 2955-2963. Cited 11 times.

Han, T.-L., Cannon, R.D., Villas-Bôas, S.G. The metabolic basis of Candida albicans morphogenesis and quorum sensing (2011) Fungal Genetics and Biology, 48 (8), pp. 747-763. Cited 54 times.

Aggio, R., Villas-Bôas, S.G., Ruggiero, K. Metab: An R package for high-throughput analysis of metabolomics data generated by GC-MS (2011) Bioinformatics, 27 (16), art. no. btr379, pp. 2316-2318. Cited 46 times.

Kvitvang, H.F.N., Andreassen, T., Adam, T., Villas-Bôas, S.G., Bruheim, P. Highly sensitive GC/MS/MS method for quantitation of amino and nonamino organic acids (2011) Analytical Chemistry, 83 (7), pp. 2705-2711. Cited 61 times.

Carneiro, S., Villas-Bôas, S.G., Ferreira, E.C., Rocha, I. Metabolic footprint analysis of recombinant Escherichia coli strains during fed-batch fermentations (2011) Molecular BioSystems, 7 (3), pp. 899-910. Cited 17 times.


Aggio, R.B.M., Ruggiero, K., Villas-Bôas, S.G. Pathway activity profiling (papi): From the metabolite profile to the metabolic pathway activity (2010) Bioinformatics, 26 (23), art. no. btq567, pp. 2969-2976. Cited 35 times.

Smart, K.F., Aggio, R.B.M., Van Houtte, J.R., Villas-Bôas, S.G. Analytical platform for metabolome analysis of microbial cells using methyl chloroformate derivatization followed by gas chromatography-mass spectrometry (2010) Nature Protocols, 5 (10), pp. 1709-1729. Cited 118 times.

Goldstone, D.C., Villas-Bôas, S.G., Till, M., Kelly, W.J., Attwood, G.T., Arcus, V.L. Structural and functional characterization of a promiscuous feruloyl esterase (Est 1 E) from the rumen bacterium Butyrivibrio proteoclasticus (2010) Proteins: Structure, Function and Bioinformatics, 78 (6), pp. 1457-1469. Cited 25 times.

Nones, K., Villas-Bôas, S.G. Evaluation of the Beneficial Effects of Phytonutrients by Metabolomics (2010) Genomics, Proteomics, and Metabolomics in Nutraceuticals and Functional Foods, pp. 287-296.


Harrison, S.J., Fraser, K., Lane, G.A., Villas-Boas, S., Rasmussen, S. A reverse-phase liquid chromatography/mass spectrometry method for the analysis of high-molecular-weight fructooligosaccharides (2009) Analytical Biochemistry, 395 (1), pp. 113-115. Cited 15 times.

Moxley, J.F., Jewett, M.C., Antoniewicz, M.R., Villas-Boas, S.G., Alpera, H., Wheeler, R.T., Tong, L., Hinnebusch, A.G., Ideker, T., Nielsen, J., Stephanopoulos, G. Linking high-resolution metabolic flux phenotypes and transcriptional regulation in yeast modulated by the global regulator Gcn4p (2009) Proceedings of the National Academy of Sciences of the United States of America, 106 (16), pp. 6477-6482. Cited 98 times.


Villas-Bôas, S.G., Moon, C.D., Noel, S., Hussein, H., Kelly, W.J., Cao, M., Lane, G.A., Cookson, A.L., Attwood, G.T. Phenotypic characterization of transposon-inserted mutants of Clostridium proteoclasticum B316T using extracellular metabolomics (2008) Journal of Biotechnology, 134 (1-2), pp. 55-63. Cited 10 times.


Villas-Bôas, S.G., Bruheim, P. Cold glycerol-saline: The promising quenching solution for accurate intracellular metabolite analysis of microbial cells (2007) Analytical Biochemistry, 370 (1), pp. 87-97. Cited 93 times.

Villas-Bôas, S.G., Bruheim, P. The potential of metabolomics tools in bioremediation studies (2007) OMICS A Journal of Integrative Biology, 11 (3), pp. 305-313. Cited 28 times.

foli008 • March 21, 2017

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